Protein Name transient receptor potential cation channel subfamily M member 7
Organism Homo sapiens
Gene ID 54822
Gene Symbol

TRPM7

UniProt Q96QT4 (TRPM7_HUMAN), H0YLN8 (H0YLN8_HUMAN), A0A024R5V1 (A0A024R5V1_HUMAN)
Relationships Total Number of functionally related compound(s) : 161
Total Number of Articles : 288
Description

transient receptor potential cation channel subfamily M member 7

Gene Summary

This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]

synonyms
  • transient receptor potential cation channel subfamily M member 7
  • LTRPC ion channel family member 7
  • channel-kinase 1
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Properties