Title : Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes.

Pub. Date : 2006 Feb

PMID : 16239374






2 Functional Relationships(s)
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1 Phosphorylation of EGFR was significantly increased in the diabetic animals, and ABT-627 treatment prevented this increase, suggesting ET-1-mediated transactivation of EGFR. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid endothelin 1 Rattus norvegicus
2 Phosphorylation of EGFR was significantly increased in the diabetic animals, and ABT-627 treatment prevented this increase, suggesting ET-1-mediated transactivation of EGFR. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid epidermal growth factor receptor Rattus norvegicus