Protein Name endothelin 1
Organism Rattus norvegicus
Gene ID 24323
Gene Symbol


UniProt P22388 (EDN1_RAT)
Relationships Total Number of functionally related compound(s) : 1418
Total Number of Articles : 2668

endothelin 1

Gene Summary

Enables endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of secretion by cell; and response to corticosteroid. Located in several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1). [provided by Alliance of Genome Resources, Apr 2022]

  • endothelin-1
  • ET-1
  • PPET1
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