Pub. Date : 2005 Nov 1
PMID : 16109731
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels. | Polyamines | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 2 | In the present study, we compared inward rectification in the Kir3.1/Kir3.4 channel, which underlies the cardiac current I(K,ACh), and the Kir2.1 channel, which underlies the cardiac current I(K,1). | Acetylcholine | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 3 | We show that Kir3.1/Kir3.4 is more sensitive to extracellular spermine block than Kir2.1, and that intracellular and extracellular polyamines can permeate Kir3.1/Kir3.4, but not Kir2.1, to a limited extent. | Spermine | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 4 | We show that Kir3.1/Kir3.4 is more sensitive to extracellular spermine block than Kir2.1, and that intracellular and extracellular polyamines can permeate Kir3.1/Kir3.4, but not Kir2.1, to a limited extent. | Spermine | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 5 | We show that Kir3.1/Kir3.4 is more sensitive to extracellular spermine block than Kir2.1, and that intracellular and extracellular polyamines can permeate Kir3.1/Kir3.4, but not Kir2.1, to a limited extent. | Polyamines | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 6 | We describe a simple kinetic model in which polyamines act as permeant blockers of Kir3.1/Kir3.4, but as relatively impermeant blockers of Kir2.1. | Polyamines | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 7 | This suggests that Kir3.1/Kir3.4 exhibits weaker inward rectification than Kir2.1 because of the difference in the balance of polyamine block and permeation of the two channels. | Polyamines | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |