| Protein Name | potassium inwardly rectifying channel subfamily J member 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3760 |
| Gene Symbol | KCNJ3 |
| UniProt | P48549 (KCNJ3_HUMAN), D2XBF0 (D2XBF0_HUMAN), D2X9V0 (D2X9V0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
105
Total Number of Articles : 85 |
Description |
potassium inwardly rectifying channel subfamily J member 3 |
| Gene Summary |
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012] |
| synonyms |
|
| Properties | |