Title : Role of aspartate 298 in mouse 5-HT3A receptor gating and modulation by extracellular Ca2+.

Pub. Date : 2005 Oct 15

PMID : 16096341






3 Functional Relationships(s)
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1 The TM2-TM3 extracellular loop is critical for activation of the Cys-loop family of ligand-gated ion channels. Cysteine tropomyosin 1, alpha Mus musculus
2 The contribution of aspartate 298 (D298), an amino acid that links the transmembrane domain 2 (TM2) to the TM2-TM3 loop, in mouse 5-hydroxytryptamine(3A) (5-HT(3A)) receptor function was probed with site-directed mutagenesis in the present study. Aspartic Acid tropomyosin 1, alpha Mus musculus
3 The contribution of aspartate 298 (D298), an amino acid that links the transmembrane domain 2 (TM2) to the TM2-TM3 loop, in mouse 5-hydroxytryptamine(3A) (5-HT(3A)) receptor function was probed with site-directed mutagenesis in the present study. d298 tropomyosin 1, alpha Mus musculus