| Protein Name | tropomyosin 1, alpha |
|---|---|
| Organism | Mus musculus |
| Gene ID | 22003 |
| Gene Symbol | Tpm1 |
| UniProt | P58771 (TPM1_MOUSE), Q564G1 (Q564G1_MOUSE), Q545Y3 (Q545Y3_MOUSE), Q8BP43 (Q8BP43_MOUSE), B7ZNL3 (B7ZNL3_MOUSE), E9Q448 (E9Q448_MOUSE), E9Q450 (E9Q450_MOUSE), G5E8R0 (G5E8R0_MOUSE), E9Q455 (E9Q455_MOUSE), E9Q452 (E9Q452_MOUSE), E9Q453 (E9Q453_MOUSE), E9Q454 (E9Q454_MOUSE), G5E8R1 (G5E8R1_MOUSE), G5E8R2 (G5E8R2_MOUSE), A0A2R2Y2P8 (A0A2R2Y2P8_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
89
Total Number of Articles : 76 |
Description |
tropomyosin 1, alpha |
| Gene Summary |
Enables actin filament binding activity. Involved in cardiac muscle contraction; positive regulation of heart rate by epinephrine; and ventricular cardiac muscle tissue morphogenesis. Acts upstream of or within in utero embryonic development. Located in myofibril. Is expressed in several structures, including central nervous system; gut; heart; limb segment; and musculature. Used to study dilated cardiomyopathy 1Y and hypertrophic cardiomyopathy 3. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1). [provided by Alliance of Genome Resources, Jun 2025] |
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