Pub. Date : 2005 Aug 9
PMID : 16051700
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. | Magnesium | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 2 | Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and trace metal ion concentration. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 3 | Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and trace metal ion concentration. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 4 | Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and trace metal ion concentration. | Metals | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 5 | Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and trace metal ion concentration. | Metals | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 6 | There is evidence that TRPM7 is constitutively active and that the number of available channels is dependent on intracellular free Mg2+ levels. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 7 | However, heterologously expressed T1482I TRPM7 produces functional channels that show an increased sensitivity to inhibition by intracellular Mg2+. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 8 | Because the incidence of ALS-G and PD-G has been associated with prolonged exposure to an environment severely deficient in Ca2+ and Mg2+, we propose that this variant TRPM7 allele confers a susceptibility genotype in such an environment. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |