PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16051700-0	2005	A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders.	Magnesium	45-54	transient receptor potential cation channel subfamily M member 7	Homo sapiens	2-7	
16051700-1	2005	Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+).	Calcium	156-163	phosphoglycerate dehydrogenase	Homo sapiens	75-79	
16051700-1	2005	Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+).	Magnesium	175-184	phosphoglycerate dehydrogenase	Homo sapiens	75-79	
16051700-1	2005	Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+).	magnesium ion	186-190	phosphoglycerate dehydrogenase	Homo sapiens	75-79	
16051700-2	2005	Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and trace metal ion concentration.	magnesium ion	210-214	transient receptor potential cation channel subfamily M member 7	Homo sapiens	0-41	
16051700-2	2005	Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and trace metal ion concentration.	magnesium ion	210-214	transient receptor potential cation channel subfamily M member 7	Homo sapiens	43-48	
16051700-2	2005	Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and trace metal ion concentration.	Metals	226-231	transient receptor potential cation channel subfamily M member 7	Homo sapiens	0-41	
16051700-2	2005	Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that has been proposed to be involved in the homeostatic regulation of intracellular Ca2+, Mg2+, and trace metal ion concentration.	Metals	226-231	transient receptor potential cation channel subfamily M member 7	Homo sapiens	43-48	
16051700-3	2005	There is evidence that TRPM7 is constitutively active and that the number of available channels is dependent on intracellular free Mg2+ levels.	magnesium ion	131-135	transient receptor potential cation channel subfamily M member 7	Homo sapiens	23-28	
16051700-6	2005	However, heterologously expressed T1482I TRPM7 produces functional channels that show an increased sensitivity to inhibition by intracellular Mg2+.	magnesium ion	142-146	transient receptor potential cation channel subfamily M member 7	Homo sapiens	41-46	
16051700-7	2005	Because the incidence of ALS-G and PD-G has been associated with prolonged exposure to an environment severely deficient in Ca2+ and Mg2+, we propose that this variant TRPM7 allele confers a susceptibility genotype in such an environment.	magnesium ion	133-137	phosphoglycerate dehydrogenase	Homo sapiens	35-39	
16051700-7	2005	Because the incidence of ALS-G and PD-G has been associated with prolonged exposure to an environment severely deficient in Ca2+ and Mg2+, we propose that this variant TRPM7 allele confers a susceptibility genotype in such an environment.	magnesium ion	133-137	transient receptor potential cation channel subfamily M member 7	Homo sapiens	168-173