Pub. Date : 2005 Feb 4
PMID : 15591230
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 2 | Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 3 | The functional significance of TRPM7 was evaluated by assessing [Mg2+]i and growth responses to Ang II in TRPM7 knockdown cells. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 4 | Acute Ang II stimulation decreased [Mg2+]i in control and TRPM7-deficient cells in a Na+-dependent manner. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 5 | Our data indicate that VSMCs possess membrane-associated, Ang II-, and aldosterone-regulated TRPM7 channels, which play a role in regulating basal [Mg2+]i, transmembrane Mg2+ transport and DNA and protein synthesis. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 6 | Our data indicate that VSMCs possess membrane-associated, Ang II-, and aldosterone-regulated TRPM7 channels, which play a role in regulating basal [Mg2+]i, transmembrane Mg2+ transport and DNA and protein synthesis. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 7 | These novel findings identify TRPM7 as a functionally important regulator of Mg2+ homeostasis and growth in VSMCs. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |