PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15591230-3 2005 Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated. magnesium ion 149-153 transient receptor potential cation channel subfamily M member 7 Homo sapiens 67-117 15591230-3 2005 Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated. magnesium ion 149-153 transient receptor potential cation channel subfamily M member 7 Homo sapiens 119-124 15591230-10 2005 The functional significance of TRPM7 was evaluated by assessing [Mg2+]i and growth responses to Ang II in TRPM7 knockdown cells. magnesium ion 65-69 transient receptor potential cation channel subfamily M member 7 Homo sapiens 31-36 15591230-11 2005 Acute Ang II stimulation decreased [Mg2+]i in control and TRPM7-deficient cells in a Na+-dependent manner. magnesium ion 36-40 angiotensinogen Homo sapiens 6-12 15591230-11 2005 Acute Ang II stimulation decreased [Mg2+]i in control and TRPM7-deficient cells in a Na+-dependent manner. magnesium ion 36-40 transient receptor potential cation channel subfamily M member 7 Homo sapiens 58-63 15591230-13 2005 Ang II-induced DNA and protein synthesis, measured by 3[H]-thymidine and 3[H]-leucine incorporation, respectively, were increased in control and nonsilencing cells, but not in TRPM7 knockdown VSMCs. Thymidine 59-68 angiotensinogen Homo sapiens 0-6 15591230-13 2005 Ang II-induced DNA and protein synthesis, measured by 3[H]-thymidine and 3[H]-leucine incorporation, respectively, were increased in control and nonsilencing cells, but not in TRPM7 knockdown VSMCs. Leucine 78-85 angiotensinogen Homo sapiens 0-6 15591230-14 2005 Our data indicate that VSMCs possess membrane-associated, Ang II-, and aldosterone-regulated TRPM7 channels, which play a role in regulating basal [Mg2+]i, transmembrane Mg2+ transport and DNA and protein synthesis. magnesium ion 148-152 angiotensinogen Homo sapiens 58-64 15591230-14 2005 Our data indicate that VSMCs possess membrane-associated, Ang II-, and aldosterone-regulated TRPM7 channels, which play a role in regulating basal [Mg2+]i, transmembrane Mg2+ transport and DNA and protein synthesis. magnesium ion 148-152 transient receptor potential cation channel subfamily M member 7 Homo sapiens 93-98 15591230-14 2005 Our data indicate that VSMCs possess membrane-associated, Ang II-, and aldosterone-regulated TRPM7 channels, which play a role in regulating basal [Mg2+]i, transmembrane Mg2+ transport and DNA and protein synthesis. magnesium ion 170-174 angiotensinogen Homo sapiens 58-64 15591230-14 2005 Our data indicate that VSMCs possess membrane-associated, Ang II-, and aldosterone-regulated TRPM7 channels, which play a role in regulating basal [Mg2+]i, transmembrane Mg2+ transport and DNA and protein synthesis. magnesium ion 170-174 transient receptor potential cation channel subfamily M member 7 Homo sapiens 93-98 15591230-15 2005 These novel findings identify TRPM7 as a functionally important regulator of Mg2+ homeostasis and growth in VSMCs. magnesium ion 77-81 transient receptor potential cation channel subfamily M member 7 Homo sapiens 30-35