Pub. Date : 2005 Feb 25
PMID : 15590691
17 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 2 | Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 3 | Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 4 | Here, we characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 5 | Here, we characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 6 | Here, we characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop. | Serine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 7 | Thr-187 and Ser-192 are conserved among species from Caenorhabditis elegans to human, and their replacement with Ala resulted in inactivation of TAK1. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 8 | Thr-187 and Ser-192 are conserved among species from Caenorhabditis elegans to human, and their replacement with Ala resulted in inactivation of TAK1. | Serine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 9 | Thr-187 and Ser-192 are conserved among species from Caenorhabditis elegans to human, and their replacement with Ala resulted in inactivation of TAK1. | Alanine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 10 | Immunoblotting with a novel phospho-TAK1 antibody revealed that TNF-alpha significantly induced the phosphorylation of endogenous TAK1 at Thr-187, and subsequently the phosphorylated forms of TAK1 rapidly disappeared. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 11 | Immunoblotting with a novel phospho-TAK1 antibody revealed that TNF-alpha significantly induced the phosphorylation of endogenous TAK1 at Thr-187, and subsequently the phosphorylated forms of TAK1 rapidly disappeared. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 12 | Immunoblotting with a novel phospho-TAK1 antibody revealed that TNF-alpha significantly induced the phosphorylation of endogenous TAK1 at Thr-187, and subsequently the phosphorylated forms of TAK1 rapidly disappeared. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 13 | Intermolecular autophosphorylation of Thr-187 was essential for TAK1 activation. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 14 | Furthermore, SB203580 and p38alpha small interfering RNA enhanced TNF-alpha-induced Thr-187 phosphorylation as well as TAK1 kinase activity, indicating that the phosphorylation is affected by p38alpha/TAB1/TAB2-mediated feedback control of TAK1. | SB 203580 | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 15 | Furthermore, SB203580 and p38alpha small interfering RNA enhanced TNF-alpha-induced Thr-187 phosphorylation as well as TAK1 kinase activity, indicating that the phosphorylation is affected by p38alpha/TAB1/TAB2-mediated feedback control of TAK1. | SB 203580 | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 16 | Furthermore, SB203580 and p38alpha small interfering RNA enhanced TNF-alpha-induced Thr-187 phosphorylation as well as TAK1 kinase activity, indicating that the phosphorylation is affected by p38alpha/TAB1/TAB2-mediated feedback control of TAK1. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |
| 17 | These results indicate critical roles of Thr-187 phosphorylation in the stress-induced rapid and transient activation of TAK1 in a signaling complex containing TAB1 and TAB2. | Threonine | mitogen-activated protein kinase kinase kinase 7 | Homo sapiens |