| Protein Name | mitogen-activated protein kinase kinase kinase 7 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6885 |
| Gene Symbol | MAP3K7 |
| UniProt | O43318 (M3K7_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
250
Total Number of Articles : 319 |
Description |
mitogen-activated protein kinase kinase kinase 7 |
| Gene Summary |
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
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