Protein Name mitogen-activated protein kinase kinase kinase 7
Organism Homo sapiens
Gene ID 6885
Gene Symbol


UniProt O43318 (M3K7_HUMAN)
Relationships Total Number of functionally related compound(s) : 250
Total Number of Articles : 319

mitogen-activated protein kinase kinase kinase 7

Gene Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

  • mitogen-activated protein kinase kinase kinase 7
  • TGF-beta activated kinase 1
  • transforming growth factor-beta-activated kinase 1
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