Title : ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels.

Pub. Date : 2004 Oct

PMID : 15308557






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 OBJECTIVE: ADP plays an important role in platelet aggregation by activating P2Y12 receptors. Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens
2 The contraction was not reduced in patients using clopidogrel, a drug inhibiting ADP-induced platelet aggregation by blocking the P2Y12 receptor. Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens
3 CONCLUSIONS: ADP acting on P2Y12 receptors not only is important for platelet activation but also stimulates vasoconstriction. Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens