Pub. Date : 2004 Aug
PMID : 15301741
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The enzyme activity of CYP2C18 to oxidate tolbutamide in postmitochondrial supernate (S9) fraction was determined by HPLC. | Tolbutamide | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 2 | In contrast, the relative survival of HepG2-CYP2C18 X2 cell was the same as that of HepG2 cell in 0.5 and 1 mmol/L of ifosfamide, but lower than that of HepG2 cell in 2 and 4 mmol/L of ifosfamide. | Ifosfamide | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 3 | In contrast, the relative survival of HepG2-CYP2C18 X2 cell was the same as that of HepG2 cell in 0.5 and 1 mmol/L of ifosfamide, but lower than that of HepG2 cell in 2 and 4 mmol/L of ifosfamide. | Ifosfamide | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 4 | CONCLUSION: CYP2C18 X1 could metabolize tolbutamide and ifosfamide efficiently. | Tolbutamide | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 5 | CONCLUSION: CYP2C18 X1 could metabolize tolbutamide and ifosfamide efficiently. | Ifosfamide | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |