PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15024092-0	2004	p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.	Cyclic AMP	65-75	mitogen-activated protein kinase 14	Mus musculus	0-3	
15024092-0	2004	p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.	Cyclic AMP	65-75	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	117-137	
15024092-1	2004	It is well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene.	Catecholamines	28-41	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	167-187	
15024092-1	2004	It is well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene.	Catecholamines	28-41	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	189-193	
15024092-1	2004	It is well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene.	Cyclic AMP	119-129	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	167-187	
15024092-1	2004	It is well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene.	Cyclic AMP	119-129	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	189-193	
15024092-1	2004	It is well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene.	Cyclic AMP	131-135	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	167-187	
15024092-1	2004	It is well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene.	Cyclic AMP	131-135	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	189-193	
15024092-3	2004	Here we demonstrate that cAMP- and protein kinase A-dependent activation of p38 mitogen-activated protein kinase (MAPK) in brown adipocytes is an indispensable step in the transcription of the UCP1 gene in mice.	Cyclic AMP	25-29	mitogen-activated protein kinase 14	Mus musculus	76-79	
15024092-3	2004	Here we demonstrate that cAMP- and protein kinase A-dependent activation of p38 mitogen-activated protein kinase (MAPK) in brown adipocytes is an indispensable step in the transcription of the UCP1 gene in mice.	Cyclic AMP	25-29	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	193-197	
15024092-4	2004	By phosphorylating activating transcription factor 2 (ATF-2) and peroxisome proliferator-activated receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a PPAR response element that both reside within a critical enhancer motif of the UCP1 gene.	Cyclic AMP	302-306	activating transcription factor 2	Mus musculus	19-52	
15024092-4	2004	By phosphorylating activating transcription factor 2 (ATF-2) and peroxisome proliferator-activated receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a PPAR response element that both reside within a critical enhancer motif of the UCP1 gene.	Cyclic AMP	302-306	activating transcription factor 2	Mus musculus	54-59	
15024092-4	2004	By phosphorylating activating transcription factor 2 (ATF-2) and peroxisome proliferator-activated receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a PPAR response element that both reside within a critical enhancer motif of the UCP1 gene.	Cyclic AMP	302-306	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	145-155	
15024092-4	2004	By phosphorylating activating transcription factor 2 (ATF-2) and peroxisome proliferator-activated receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a PPAR response element that both reside within a critical enhancer motif of the UCP1 gene.	Cyclic AMP	302-306	mitogen-activated protein kinase 14	Mus musculus	207-215	
15024092-4	2004	By phosphorylating activating transcription factor 2 (ATF-2) and peroxisome proliferator-activated receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a PPAR response element that both reside within a critical enhancer motif of the UCP1 gene.	Cyclic AMP	302-306	peroxisome proliferator activated receptor alpha	Mus musculus	115-119	
15024092-5	2004	Activation of ATF-2 by p38 MAPK additionally serves as the cAMP sensor that increases expression of the PGC-1alpha gene itself in brown adipose tissue.	Cyclic AMP	59-63	activating transcription factor 2	Mus musculus	14-19	
15024092-5	2004	Activation of ATF-2 by p38 MAPK additionally serves as the cAMP sensor that increases expression of the PGC-1alpha gene itself in brown adipose tissue.	Cyclic AMP	59-63	mitogen-activated protein kinase 14	Mus musculus	23-26	
15024092-5	2004	Activation of ATF-2 by p38 MAPK additionally serves as the cAMP sensor that increases expression of the PGC-1alpha gene itself in brown adipose tissue.	Cyclic AMP	59-63	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	104-114	
15024092-6	2004	In conclusion, our findings illustrate that by orchestrating the activity of multiple transcription factors, p38 MAPK is a central mediator of the cAMP signaling mechanism of brown fat that promotes thermogenesis.	Cyclic AMP	147-151	mitogen-activated protein kinase 14	Mus musculus	109-117