Title : Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt.

Pub. Date : 2004 Mar

PMID : 14999683






3 Functional Relationships(s)
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1 Pretreatment of PHH with the PI3K inhibitor LY294002 as well as adenoviral transduction of dominant negative Akt1 prevented HGF-mediated Mcl-1 induction and reversed the antiapoptotic effects of HGF. 4,5,6,7-tetrachlorophthalide hepatocyte growth factor Homo sapiens
2 Pretreatment of PHH with the PI3K inhibitor LY294002 as well as adenoviral transduction of dominant negative Akt1 prevented HGF-mediated Mcl-1 induction and reversed the antiapoptotic effects of HGF. 4,5,6,7-tetrachlorophthalide MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 Pretreatment of PHH with the PI3K inhibitor LY294002 as well as adenoviral transduction of dominant negative Akt1 prevented HGF-mediated Mcl-1 induction and reversed the antiapoptotic effects of HGF. 4,5,6,7-tetrachlorophthalide hepatocyte growth factor Homo sapiens