Pub. Date : 2004 Feb 20
PMID : 14662774
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. | Troglitazone | growth differentiation factor 15 | Homo sapiens |
| 2 | In this report, we show that the expression of the antitumorigenic and/or pro-apoptotic gene NAG-1 (nonsteroidal anti-inflammatory drug-activated gene-1) is induced by TGZ and correlates with EGR-1 induction. | Troglitazone | growth differentiation factor 15 | Homo sapiens |
| 3 | In this report, we show that the expression of the antitumorigenic and/or pro-apoptotic gene NAG-1 (nonsteroidal anti-inflammatory drug-activated gene-1) is induced by TGZ and correlates with EGR-1 induction. | Troglitazone | growth differentiation factor 15 | Homo sapiens |
| 4 | In contrast, PGJ2 induced NAG-1 protein expression, but PGJ2 may not affect the same region that TGZ does in the NAG-1 promoter. | 15-deoxy-delta(12,14)-prostaglandin J2 | growth differentiation factor 15 | Homo sapiens |
| 5 | The effect of PGJ2 is probably PPARgamma-dependent because a PPARgamma antagonist inhibited the PGJ2-induced expression of NAG-1. | 15-deoxy-delta(12,14)-prostaglandin J2 | growth differentiation factor 15 | Homo sapiens |
| 6 | The effect of PGJ2 is probably PPARgamma-dependent because a PPARgamma antagonist inhibited the PGJ2-induced expression of NAG-1. | 15-deoxy-delta(12,14)-prostaglandin J2 | growth differentiation factor 15 | Homo sapiens |
| 7 | TGZ-induced NAG-1 expression was not inhibited by the PPARgamma antagonist. | Troglitazone | growth differentiation factor 15 | Homo sapiens |