Protein Name growth differentiation factor 15
Organism Homo sapiens
Gene ID 9518
Gene Symbol


UniProt Q99988 (GDF15_HUMAN)
Relationships Total Number of functionally related compound(s) : 360
Total Number of Articles : 432

growth differentiation factor 15

Gene Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]

  • growth/differentiation factor 15
  • NRG-1
  • NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
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