Pub. Date : 2003 Oct
PMID : 14578467
2 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Using doxorubicin treatment in the HCT116 colon cancer cell line, we have shown that MIC-1 secretion into culture media is correlated with p53 pathway activation as measured by the up-regulation of its downstream transcriptional target p21. | Doxorubicin | growth differentiation factor 15 | Homo sapiens | ||
| 2 | Treatment of these animals with a single dose of doxorubicin led to activation of the p53 pathway and a nearly 4-fold elevation of the plasma MIC-1 level, which was paralleled by p21 induction in the tumor xenografts. | Doxorubicin | growth differentiation factor 15 | Homo sapiens | ||