PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14578467-4 2003 Using doxorubicin treatment in the HCT116 colon cancer cell line, we have shown that MIC-1 secretion into culture media is correlated with p53 pathway activation as measured by the up-regulation of its downstream transcriptional target p21. Doxorubicin 6-17 growth differentiation factor 15 Homo sapiens 85-90 14578467-4 2003 Using doxorubicin treatment in the HCT116 colon cancer cell line, we have shown that MIC-1 secretion into culture media is correlated with p53 pathway activation as measured by the up-regulation of its downstream transcriptional target p21. Doxorubicin 6-17 tumor protein p53 Homo sapiens 139-142 14578467-6 2003 Treatment of these animals with a single dose of doxorubicin led to activation of the p53 pathway and a nearly 4-fold elevation of the plasma MIC-1 level, which was paralleled by p21 induction in the tumor xenografts. Doxorubicin 49-60 tumor protein p53 Homo sapiens 86-89 14578467-6 2003 Treatment of these animals with a single dose of doxorubicin led to activation of the p53 pathway and a nearly 4-fold elevation of the plasma MIC-1 level, which was paralleled by p21 induction in the tumor xenografts. Doxorubicin 49-60 growth differentiation factor 15 Homo sapiens 142-147 14578467-6 2003 Treatment of these animals with a single dose of doxorubicin led to activation of the p53 pathway and a nearly 4-fold elevation of the plasma MIC-1 level, which was paralleled by p21 induction in the tumor xenografts. Doxorubicin 49-60 H3 histone pseudogene 16 Homo sapiens 179-182