Pub. Date : 1992 Oct 16
PMID : 1359141
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These imidazo[1,2-a]pyrazines were evaluated for their binding affinity to the alpha 1, alpha 2, beta 1, and beta 2 adrenergic receptors as well as their ability to lower blood glucose in insulin resistant hyperglycemic ob/ob mice. | imidazo(1,2-a)pyrazine | hemoglobin, beta adult major chain | Mus musculus |
| 2 | Modifications on 8-(1-piperazinyl)imidazo[1,2-a]pyrazine (4) reduced alpha 2 binding, lowered hypoglycemic potency, and showed variations in binding to the alpha 1, beta 1, and beta 2 adrenergic receptors. | 8-(1-piperazinyl)imidazo(1,2-a)pyrazine | hemoglobin, beta adult major chain | Mus musculus |
| 3 | Receptor binding was modified by use of a 4-methylpiperazine moiety which reduced alpha 1 and beta 1 binding while retaining some hypoglycemic activity. | 1-methylpiperazine | hemoglobin, beta adult major chain | Mus musculus |