Protein Name hemoglobin, beta adult major chain
Organism Mus musculus
Gene ID 15129
Gene Symbol


UniProt P02088 (HBB1_MOUSE), A8DUK0 (A8DUK0_MOUSE)
Relationships Total Number of functionally related compound(s) : 312
Total Number of Articles : 338

hemoglobin, beta adult major chain

Gene Summary

This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a "single" haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a "diffuse" haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta-major adult gene found in the "diffuse" haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the "single" haplotype, while the "diffuse" haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]

  • hemoglobin subunit beta-1
  • beta maj
  • beta major globin
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