PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1359141-2	1992	These imidazo[1,2-a]pyrazines were evaluated for their binding affinity to the alpha 1, alpha 2, beta 1, and beta 2 adrenergic receptors as well as their ability to lower blood glucose in insulin resistant hyperglycemic ob/ob mice.	imidazo(1,2-a)pyrazine	6-29	hemoglobin, beta adult major chain	Mus musculus	79-115	
1359141-3	1992	Modifications on 8-(1-piperazinyl)imidazo[1,2-a]pyrazine (4) reduced alpha 2 binding, lowered hypoglycemic potency, and showed variations in binding to the alpha 1, beta 1, and beta 2 adrenergic receptors.	8-(1-piperazinyl)imidazo(1,2-a)pyrazine	17-56	hemoglobin, beta adult major chain	Mus musculus	165-171	
1359141-3	1992	Modifications on 8-(1-piperazinyl)imidazo[1,2-a]pyrazine (4) reduced alpha 2 binding, lowered hypoglycemic potency, and showed variations in binding to the alpha 1, beta 1, and beta 2 adrenergic receptors.	8-(1-piperazinyl)imidazo(1,2-a)pyrazine	17-56	hemoglobin, beta adult minor chain	Mus musculus	177-183	
1359141-5	1992	Receptor binding was modified by use of a 4-methylpiperazine moiety which reduced alpha 1 and beta 1 binding while retaining some hypoglycemic activity.	1-methylpiperazine	42-60	hemoglobin, beta adult major chain	Mus musculus	94-100	
lipase C beta 1	Homo sapiens	109-115	
8395015-1	1993	Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phosphatidylinositol-specific phospholipase C (PI-PLC) generates two second messengers, inositol 1,4,5-trisphosphate and 1,2-diacylglycerol.	Inositol 1,4,5-Trisphosphate	150-178	oleate-activated transcription factor PIP2	Saccharomyces cerevisiae S288C	53-57	
8395015-1	1993	Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phosphatidylinositol-specific phospholipase C (PI-PLC) generates two second messengers, inositol 1,4,5-trisphosphate and 1,2-diacylglycerol.	Inositol 1,4,5-Trisphosphate	150-178	phospholipase C beta 1	Homo sapiens	109-115	
8395015-1	1993	Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phosphatidylinositol-specific phospholipase C (PI-PLC) generates two second messengers, inositol 1,4,5-trisphosphate and 1,2-diacylglycerol.	1,2-diacylglycerol	183-201	oleate-activated transcription factor PIP2	Saccharomyces cerevisiae S288C	53-57	
8395015-1	1993	Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phosphatidylinositol-specific phospholipase C (PI-PLC) generates two second messengers, inositol 1,4,5-trisphosphate and 1,2-diacylglycerol.	1,2-diacylglycerol	183-201	phospholipase C beta 1	Homo sapiens	109-115	
8395015-4	1993	Plc1p, modified by in-frame insertion of a His6 tract and a c-myc epitope near its amino terminus, was overexpressed from the GAL1 promoter, partially purified by nickel chelate affinity chromatography, and shown to be an active PLC enzyme in vitro with properties similar to those of its mammalian counterparts.	Nickel	163-169	phospholipase C gamma 1	Homo sapiens	0-5	
8395015-5	1993	Plc1p activity was strictly Ca2+ dependent: at a high Ca2+ concentration (0.1 mM), the enzyme hydrolyzed PIP2 at a faster rate than phosphatidylinositol, and at a low Ca2+ concentration (0.5 microM), it hydrolyzed PIP2 exclusively.	Phosphatidylinositols	132-152	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	0-5	
8395015-6	1993	Cells carrying either of two different deletion-insertion mutations (plc1 delta 1::HIS3 and plc1 delta 2::LEU2) were viable but displayed several distinctive phenotypes, including temperature-sensitive growth (inviable above 35 degrees C), osmotic sensitivity, and defects in the utilization of galactose, raffinose, and glycerol at permissive temperatures (23 to 30 degrees C).	Galactose	295-304	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	69-73	
8395015-6	1993	Cells carrying either of two different deletion-insertion mutations (plc1 delta 1::HIS3 and plc1 delta 2::LEU2) were viable but displayed several distinctive phenotypes, including temperature-sensitive growth (inviable above 35 degrees C), osmotic sensitivity, and defects in the utilization of galactose, raffinose, and glycerol at permissive temperatures (23 to 30 degrees C).	Raffinose	306-315	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	69-73	
8395015-6	1993	Cells carrying either of two different deletion-insertion mutations (plc1 delta 1::HIS3 and plc1 delta 2::LEU2) were viable but displayed several distinctive phenotypes, including temperature-sensitive growth (inviable above 35 degrees C), osmotic sensitivity, and defects in the utilization of galactose, raffinose, and glycerol at permissive temperatures (23 to 30 degrees C).	Glycerol	321-329	phosphatidylinositol phospholipase C	Saccharomyces cerevisiae S288C	69-73