Pub. Date : 2002
PMID : 12373538
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that the selective antagonist of the mGluR5 subtype MPEP in a dose of 5 mg/kg diminished basal and veratridine (100 microM)-stimulated dopamine release in rat striatum in an in vivo model of microdialysis. | 6-methyl-2-(phenylethynyl)pyridine | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 2 | It is concluded that the MPEP-produced blockade of mGluR5 situated on dopaminergic cells, or the suppression of glutamate release in the subthalamic nucleus or substantia nigra pars reticulata may directly and indirectly cause a decrease in striatal dopamine release. | 6-methyl-2-(phenylethynyl)pyridine | glutamate receptor, ionotropic, kainate 1 | Mus musculus |