Pub. Date : 2002 Sep 25
PMID : 12297313
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization. | Glucose | neurogenic differentiation 1 | Mus musculus |
| 2 | Here we show NeuroD1 is primarily cytoplasmic at non-stimulating glucose concentrations (i.e. 3 mM) in MIN6 beta-cells and nuclear under stimulating conditions (i.e. 20 mM). | Glucose | neurogenic differentiation 1 | Mus musculus |
| 3 | Treatment with the MEK inhibitor PD98059 or substitution of a serine for an alanine at a potential mitogen-activated protein kinase phosphorylation site (S274) in NeuroD1 significantly increased the cytoplasmic level at 20 mM glucose. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | neurogenic differentiation 1 | Mus musculus |
| 4 | Treatment with the MEK inhibitor PD98059 or substitution of a serine for an alanine at a potential mitogen-activated protein kinase phosphorylation site (S274) in NeuroD1 significantly increased the cytoplasmic level at 20 mM glucose. | Serine | neurogenic differentiation 1 | Mus musculus |
| 5 | Treatment with the MEK inhibitor PD98059 or substitution of a serine for an alanine at a potential mitogen-activated protein kinase phosphorylation site (S274) in NeuroD1 significantly increased the cytoplasmic level at 20 mM glucose. | Alanine | neurogenic differentiation 1 | Mus musculus |
| 6 | Treatment with the MEK inhibitor PD98059 or substitution of a serine for an alanine at a potential mitogen-activated protein kinase phosphorylation site (S274) in NeuroD1 significantly increased the cytoplasmic level at 20 mM glucose. | Glucose | neurogenic differentiation 1 | Mus musculus |
| 7 | The rise in NeuroD1-mediated transcription in response to glucose also correlated with the change in sub-cellular localization, a response attenuated by PD98059. | Glucose | neurogenic differentiation 1 | Mus musculus |
| 8 | The rise in NeuroD1-mediated transcription in response to glucose also correlated with the change in sub-cellular localization, a response attenuated by PD98059. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | neurogenic differentiation 1 | Mus musculus |
| 9 | The data strongly suggest that glucose-stimulation of the MEK-ERK signalling pathway influences NeuroD1 activity at least partially through effects on sub-cellular localization. | Glucose | neurogenic differentiation 1 | Mus musculus |