Pub. Date : 2002 Jun
PMID : 12021184
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Endocrine disrupter bisphenol a induces orphan nuclear receptor Nur77 gene expression and steroidogenesis in mouse testicular Leydig cells. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 2 | The aim of the current study was to investigate the potential role of bisphenol A (BPA) on orphan nuclear receptor Nur77 gene expression and steroidogenesis. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 3 | The aim of the current study was to investigate the potential role of bisphenol A (BPA) on orphan nuclear receptor Nur77 gene expression and steroidogenesis. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 4 | Northern blot analysis demonstrated that BPA transiently induced Nur77 mRNA expression, and protein kinase inhibitor H-89 and PD98059 strongly inhibited the induction of BPA-mediated Nur77 gene expression in mouse Leydig tumor cell line, K28. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 5 | Northern blot analysis demonstrated that BPA transiently induced Nur77 mRNA expression, and protein kinase inhibitor H-89 and PD98059 strongly inhibited the induction of BPA-mediated Nur77 gene expression in mouse Leydig tumor cell line, K28. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 6 | Northern blot analysis demonstrated that BPA transiently induced Nur77 mRNA expression, and protein kinase inhibitor H-89 and PD98059 strongly inhibited the induction of BPA-mediated Nur77 gene expression in mouse Leydig tumor cell line, K28. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 7 | Transient transfection assay demonstrated that BPA increased Nur77 gene promoter activity and Nur77 transactivation, whereas BPA did not significantly affect the interaction of Nur77 with its corepressor. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 8 | Transient transfection assay demonstrated that BPA increased Nur77 gene promoter activity and Nur77 transactivation, whereas BPA did not significantly affect the interaction of Nur77 with its corepressor. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 9 | Transient transfection assay demonstrated that BPA increased Nur77 gene promoter activity and Nur77 transactivation, whereas BPA did not significantly affect the interaction of Nur77 with its corepressor. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 10 | Furthermore, BPA increased progesterone biosynthesis in K28 cells, which was suppressed by overexpression of dominant negative Nur77. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 11 | Finally, BPA injection to prepubertal mice revealed that the expression of Nur77 mRNA was elevated, and this induction was correlated with increased concentration of testicular T in vivo. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 12 | Taken together, these results demonstrated that BPA induces Nur77 gene expression and subsequently alters the steroidogenesis in testicular Leydig cells. | bisphenol A | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |