PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12021184-0	2002	Endocrine disrupter bisphenol a induces orphan nuclear receptor Nur77 gene expression and steroidogenesis in mouse testicular Leydig cells.	bisphenol A	20-31	nuclear receptor subfamily 4, group A, member 1	Mus musculus	64-69	
12021184-2	2002	The aim of the current study was to investigate the potential role of bisphenol A (BPA) on orphan nuclear receptor Nur77 gene expression and steroidogenesis.	bisphenol A	70-81	nuclear receptor subfamily 4, group A, member 1	Mus musculus	115-120	
12021184-2	2002	The aim of the current study was to investigate the potential role of bisphenol A (BPA) on orphan nuclear receptor Nur77 gene expression and steroidogenesis.	bisphenol A	83-86	nuclear receptor subfamily 4, group A, member 1	Mus musculus	115-120	
12021184-3	2002	Northern blot analysis demonstrated that BPA transiently induced Nur77 mRNA expression, and protein kinase inhibitor H-89 and PD98059 strongly inhibited the induction of BPA-mediated Nur77 gene expression in mouse Leydig tumor cell line, K28.	bisphenol A	41-44	nuclear receptor subfamily 4, group A, member 1	Mus musculus	65-70	
12021184-3	2002	Northern blot analysis demonstrated that BPA transiently induced Nur77 mRNA expression, and protein kinase inhibitor H-89 and PD98059 strongly inhibited the induction of BPA-mediated Nur77 gene expression in mouse Leydig tumor cell line, K28.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	126-133	nuclear receptor subfamily 4, group A, member 1	Mus musculus	183-188	
12021184-3	2002	Northern blot analysis demonstrated that BPA transiently induced Nur77 mRNA expression, and protein kinase inhibitor H-89 and PD98059 strongly inhibited the induction of BPA-mediated Nur77 gene expression in mouse Leydig tumor cell line, K28.	bisphenol A	170-173	nuclear receptor subfamily 4, group A, member 1	Mus musculus	183-188	
12021184-5	2002	Transient transfection assay demonstrated that BPA increased Nur77 gene promoter activity and Nur77 transactivation, whereas BPA did not significantly affect the interaction of Nur77 with its corepressor.	bisphenol A	47-50	nuclear receptor subfamily 4, group A, member 1	Mus musculus	61-66	
12021184-5	2002	Transient transfection assay demonstrated that BPA increased Nur77 gene promoter activity and Nur77 transactivation, whereas BPA did not significantly affect the interaction of Nur77 with its corepressor.	bisphenol A	47-50	nuclear receptor subfamily 4, group A, member 1	Mus musculus	94-99	
12021184-5	2002	Transient transfection assay demonstrated that BPA increased Nur77 gene promoter activity and Nur77 transactivation, whereas BPA did not significantly affect the interaction of Nur77 with its corepressor.	bisphenol A	47-50	nuclear receptor subfamily 4, group A, member 1	Mus musculus	94-99	
12021184-6	2002	Furthermore, BPA increased progesterone biosynthesis in K28 cells, which was suppressed by overexpression of dominant negative Nur77.	bisphenol A	13-16	nuclear receptor subfamily 4, group A, member 1	Mus musculus	127-132	
12021184-7	2002	Finally, BPA injection to prepubertal mice revealed that the expression of Nur77 mRNA was elevated, and this induction was correlated with increased concentration of testicular T in vivo.	bisphenol A	9-12	nuclear receptor subfamily 4, group A, member 1	Mus musculus	75-80	
12021184-8	2002	Taken together, these results demonstrated that BPA induces Nur77 gene expression and subsequently alters the steroidogenesis in testicular Leydig cells.	bisphenol A	48-51	nuclear receptor subfamily 4, group A, member 1	Mus musculus	60-65