Title : The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1.

Pub. Date : 2002 Mar 8

PMID : 11866427






3 Functional Relationships(s)
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1 We also demonstrate that both the Tyk-2 and Jak-1 kinases are required for activation of the CrkL/Rap1 pathway, as the Type I IFN-dependent GTP-bound form of Rap1 is inhibited by overexpression of dominant-negative Tyk-2 or Jak-1 mutants and is defective in cells lacking Tyk-2 or Jak-1. Guanosine Triphosphate Janus kinase 1 Mus musculus
2 We also demonstrate that both the Tyk-2 and Jak-1 kinases are required for activation of the CrkL/Rap1 pathway, as the Type I IFN-dependent GTP-bound form of Rap1 is inhibited by overexpression of dominant-negative Tyk-2 or Jak-1 mutants and is defective in cells lacking Tyk-2 or Jak-1. Guanosine Triphosphate Janus kinase 1 Mus musculus
3 We also demonstrate that both the Tyk-2 and Jak-1 kinases are required for activation of the CrkL/Rap1 pathway, as the Type I IFN-dependent GTP-bound form of Rap1 is inhibited by overexpression of dominant-negative Tyk-2 or Jak-1 mutants and is defective in cells lacking Tyk-2 or Jak-1. Guanosine Triphosphate Janus kinase 1 Mus musculus