| Protein Name | Janus kinase 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16451 |
| Gene Symbol | Jak1 |
| UniProt | B1ASP2 (B1ASP2_MOUSE), Q3U8P8 (Q3U8P8_MOUSE), Q3URU8 (Q3URU8_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
123
Total Number of Articles : 202 |
Description |
Janus kinase 1 |
| Gene Summary |
Enables growth hormone receptor binding activity and protein tyrosine kinase activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Predicted to be part of receptor complex. Predicted to be active in cytoplasmic side of plasma membrane and cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human JAK1 (Janus kinase 1). [provided by Alliance of Genome Resources, Jun 2025] |
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