Title : The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different.

Pub. Date : 2001 Dec 14

PMID : 11598113






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Substitution of Val(2322) for leucine (as in IP(3)R1) or isoleucine (as in RyR2) decreased the binding efficiency and shifted the selectivity to FKBP12.6; substitution of Val(2322) for aspartate completely abolished the FKBP interaction. Isoleucine FKBP prolyl isomerase 1B Homo sapiens