PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11598113-5 2001 By using proteolytic mapping and site-directed mutagenesis, we pinpointed Val(2322), located in the central modulatory domain of the RyR3, as a critical residue for the interaction of RyR3 with FKBPs. Valine 74-77 ryanodine receptor 3 Homo sapiens 133-137 11598113-5 2001 By using proteolytic mapping and site-directed mutagenesis, we pinpointed Val(2322), located in the central modulatory domain of the RyR3, as a critical residue for the interaction of RyR3 with FKBPs. Valine 74-77 ryanodine receptor 3 Homo sapiens 184-188 11598113-6 2001 Substitution of Val(2322) for leucine (as in IP(3)R1) or isoleucine (as in RyR2) decreased the binding efficiency and shifted the selectivity to FKBP12.6; substitution of Val(2322) for aspartate completely abolished the FKBP interaction. Isoleucine 57-67 FKBP prolyl isomerase 1B Homo sapiens 145-153