Pub. Date : 2000 Oct
PMID : 11026649
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Low-dose indapamide also reduced significantly plasma (-65%) and LV angiotensin-converting enzyme (ACE) activities (-74%) as well as LV mRNA levels (-24%). | Indapamide | angiotensin I converting enzyme | Rattus norvegicus |
| 2 | Low-dose indapamide also reduced significantly plasma (-65%) and LV angiotensin-converting enzyme (ACE) activities (-74%) as well as LV mRNA levels (-24%). | Indapamide | angiotensin I converting enzyme | Rattus norvegicus |
| 3 | Furthermore, high-dose indapamide increased plasma renin activity substantially, whereas low-dose treatment was without effect on circulating renin. | Indapamide | renin | Rattus norvegicus |
| 4 | In conclusion, in rats with continuous LV pressure-overload low-dose treatment with indapamide leads to mild regression of cardiac hypertrophy, accompanied by a downregulation of components of the cardiac renin-angiotensin system. | Indapamide | renin | Rattus norvegicus |