Title : Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.

Pub. Date : 2000 Sep

PMID : 10976913






2 Functional Relationships(s)
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Protein Name
Organism
1 Consistent with the effects on STAT5B phosphorylation, tyrosine-to-phenylalanine mutation of tyrosine 595 prolongs the duration of tyrosyl phosphorylation of GHR and JAK2. Tyrosine Janus kinase 2 Rattus norvegicus
2 Consistent with the effects on STAT5B phosphorylation, tyrosine-to-phenylalanine mutation of tyrosine 595 prolongs the duration of tyrosyl phosphorylation of GHR and JAK2. cyclo(tyrosyl-tyrosyl) Janus kinase 2 Rattus norvegicus