PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10976913-0	2000	Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.	cyclo(tyrosyl-tyrosyl)	88-95	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	16-21	
10976913-0	2000	Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.	cyclo(tyrosyl-tyrosyl)	88-95	growth hormone receptor	Rattus norvegicus	38-66	
10976913-0	2000	Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.	cyclo(tyrosyl-tyrosyl)	88-95	growth hormone receptor	Rattus norvegicus	115-126	
10976913-4	2000	We demonstrate that the SH2 domains of SHP-2 bind directly to tyrosyl phosphorylated GHR from GH-treated cells.	cyclo(tyrosyl-tyrosyl)	62-69	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	39-44	
10976913-4	2000	We demonstrate that the SH2 domains of SHP-2 bind directly to tyrosyl phosphorylated GHR from GH-treated cells.	cyclo(tyrosyl-tyrosyl)	62-69	growth hormone receptor	Rattus norvegicus	85-88	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	0-8	growth hormone receptor	Rattus norvegicus	58-61	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	0-8	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	115-120	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	0-8	growth hormone receptor	Rattus norvegicus	126-129	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	0-8	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	238-243	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	0-8	growth hormone receptor	Rattus norvegicus	126-129	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	38-46	growth hormone receptor	Rattus norvegicus	58-61	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	38-46	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	115-120	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	38-46	growth hormone receptor	Rattus norvegicus	126-129	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	38-46	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	238-243	
10976913-5	2000	Tyrosine-to-phenylalanine mutation of tyrosine 595 of rat GHR greatly diminishes association of the SH2 domains of SHP-2 with GHR, and tyrosine-to-phenylalanine mutation of tyrosine 487 partially reduces association of the SH2 domains of SHP-2 with GHR.	Tyrosine	38-46	growth hormone receptor	Rattus norvegicus	126-129	
10976913-6	2000	Mutation of tyrosine 595 dramatically prolongs the duration of tyrosyl phosphorylation of the signal transducer and activator of transcription STAT5B in response to GH, while mutation of tyrosine 487 moderately prolongs the duration of STAT5B tyrosyl phosphorylation.	Tyrosine	12-20	signal transducer and activator of transcription 5B	Rattus norvegicus	143-149	
10976913-6	2000	Mutation of tyrosine 595 dramatically prolongs the duration of tyrosyl phosphorylation of the signal transducer and activator of transcription STAT5B in response to GH, while mutation of tyrosine 487 moderately prolongs the duration of STAT5B tyrosyl phosphorylation.	Tyrosine	12-20	signal transducer and activator of transcription 5B	Rattus norvegicus	236-242	
10976913-6	2000	Mutation of tyrosine 595 dramatically prolongs the duration of tyrosyl phosphorylation of the signal transducer and activator of transcription STAT5B in response to GH, while mutation of tyrosine 487 moderately prolongs the duration of STAT5B tyrosyl phosphorylation.	cyclo(tyrosyl-tyrosyl)	63-70	signal transducer and activator of transcription 5B	Rattus norvegicus	143-149	
10976913-7	2000	Consistent with the effects on STAT5B phosphorylation, tyrosine-to-phenylalanine mutation of tyrosine 595 prolongs the duration of tyrosyl phosphorylation of GHR and JAK2.	Tyrosine	55-63	signal transducer and activator of transcription 5B	Rattus norvegicus	31-37	
10976913-7	2000	Consistent with the effects on STAT5B phosphorylation, tyrosine-to-phenylalanine mutation of tyrosine 595 prolongs the duration of tyrosyl phosphorylation of GHR and JAK2.	Tyrosine	55-63	growth hormone receptor	Rattus norvegicus	158-161	
10976913-7	2000	Consistent with the effects on STAT5B phosphorylation, tyrosine-to-phenylalanine mutation of tyrosine 595 prolongs the duration of tyrosyl phosphorylation of GHR and JAK2.	Tyrosine	55-63	Janus kinase 2	Rattus norvegicus	166-170	
10976913-7	2000	Consistent with the effects on STAT5B phosphorylation, tyrosine-to-phenylalanine mutation of tyrosine 595 prolongs the duration of tyrosyl phosphorylation of GHR and JAK2.	cyclo(tyrosyl-tyrosyl)	131-138	signal transducer and activator of transcription 5B	Rattus norvegicus	31-37	
10976913-7	2000	Consistent with the effects on STAT5B phosphorylation, tyrosine-to-phenylalanine mutation of tyrosine 595 prolongs the duration of tyrosyl phosphorylation of GHR and JAK2.	cyclo(tyrosyl-tyrosyl)	131-138	growth hormone receptor	Rattus norvegicus	158-161	
10976913-7	2000	Consistent with the effects on STAT5B phosphorylation, tyrosine-to-phenylalanine mutation of tyrosine 595 prolongs the duration of tyrosyl phosphorylation of GHR and JAK2.	cyclo(tyrosyl-tyrosyl)	131-138	Janus kinase 2	Rattus norvegicus	166-170	
10976913-8	2000	These data suggest that tyrosine 595 is a major site of interaction of GHR with SHP-2, and that GHR-bound SHP-2 negatively regulates GHR/JAK2 and STAT5B signaling.	Tyrosine	24-32	growth hormone receptor	Rattus norvegicus	71-74	
10976913-8	2000	These data suggest that tyrosine 595 is a major site of interaction of GHR with SHP-2, and that GHR-bound SHP-2 negatively regulates GHR/JAK2 and STAT5B signaling.	Tyrosine	24-32	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	80-85