Protein Name Janus kinase 2
Organism Rattus norvegicus
Gene ID 24514
Gene Symbol

Jak2

UniProt Q62689 (JAK2_RAT)
Relationships Total Number of functionally related compound(s) : 336
Total Number of Articles : 474
Description

Janus kinase 2

Gene Summary

Enables several functions, including insulin receptor substrate binding activity; protein C-terminus binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of protein transport; and regulation of apoptotic process. Located in cytosol; euchromatin; and nucleolus. Is active in glutamatergic synapse and postsynapse. Used to study several diseases, including hyperuricemia; liver disease (multiple); non-alcoholic fatty liver disease; retinal detachment; and thrombocytosis. Biomarker of gastrointestinal system cancer (multiple); heart disease; liver cirrhosis; and obesity. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • tyrosine-protein kinase JAK2
  • JAK-2
  • Janus kinase 2 (a protein tyrosine kinase)
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Properties