Pub. Date : 2000 Sep
PMID : 10945855
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl). | 4-fluorofentanyl | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 2 | We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl). | Fentanyl | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 3 | We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl). | Phosphorus | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 4 | We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl). | fluorofentanyl | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 5 | A comparison of ligand efficacy revealed that morphine, fentanyl, and its analogs less efficiently activate GIRK1/GIRK2 channels through human mu-opioid receptor than [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin. | Morphine | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 6 | A comparison of ligand efficacy revealed that morphine, fentanyl, and its analogs less efficiently activate GIRK1/GIRK2 channels through human mu-opioid receptor than [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin. | Fentanyl | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 7 | A comparison of ligand efficacy revealed that morphine, fentanyl, and its analogs less efficiently activate GIRK1/GIRK2 channels through human mu-opioid receptor than [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin. | gly(5)-ol | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 8 | Changes in EC(50) values for the W318L and W318Y/H319Y mu-opioid receptors show a partial contribution of these residues to the decreased GIRK1/GIRK2 channel activation by fentanyl analogs through kappa- and delta-opioid receptors. | Fentanyl | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 9 | The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor. | 4-fluorofentanyl | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 10 | The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor. | 4-fluorophenylpropanamide | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 11 | The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor. | Tryptophan | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 12 | The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor. | Histidine | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |