PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10945855-2	2000	We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl).	4-fluorofentanyl	20-36	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	61-66	
10945855-2	2000	We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl).	4-fluorofentanyl	20-36	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	67-72	
10945855-2	2000	We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl).	Fentanyl	28-36	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	61-66	
10945855-2	2000	We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl).	Fentanyl	28-36	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	67-72	
10945855-2	2000	We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl).	Phosphorus	20-21	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	61-66	
10945855-2	2000	We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl).	Phosphorus	20-21	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	67-72	
10945855-2	2000	We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl).	fluorofentanyl	22-36	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	61-66	
10945855-2	2000	We demonstrate that p-fluorofentanyl more potently activates GIRK1/GIRK2 channels through opioid receptors than fentanyl and that the p-fluoro substitution also changes the potency profile from mu > kappa > delta (fentanyl) to mu > delta > or = kappa (p-fluorofentanyl).	fluorofentanyl	22-36	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	67-72	
10945855-3	2000	A comparison of ligand efficacy revealed that morphine, fentanyl, and its analogs less efficiently activate GIRK1/GIRK2 channels through human mu-opioid receptor than [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin.	Morphine	46-54	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	108-113	
10945855-3	2000	A comparison of ligand efficacy revealed that morphine, fentanyl, and its analogs less efficiently activate GIRK1/GIRK2 channels through human mu-opioid receptor than [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin.	Morphine	46-54	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	114-119	
10945855-3	2000	A comparison of ligand efficacy revealed that morphine, fentanyl, and its analogs less efficiently activate GIRK1/GIRK2 channels through human mu-opioid receptor than [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin.	Fentanyl	56-64	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	108-113	
10945855-3	2000	A comparison of ligand efficacy revealed that morphine, fentanyl, and its analogs less efficiently activate GIRK1/GIRK2 channels through human mu-opioid receptor than [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin.	Fentanyl	56-64	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	114-119	
10945855-3	2000	A comparison of ligand efficacy revealed that morphine, fentanyl, and its analogs less efficiently activate GIRK1/GIRK2 channels through human mu-opioid receptor than [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin.	gly(5)-ol	189-198	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	108-113	
10945855-4	2000	Using site-directed mutagenesis, we investigated whether mutating residues Trp-318 and His-319 to their corresponding residues in kappa- and delta-opioid receptors provides the molecular basis for mu/delta selectivity and mu/kappa selectivity.	Tryptophan	75-78	opioid receptor kappa 1	Homo sapiens	130-163	
10945855-4	2000	Using site-directed mutagenesis, we investigated whether mutating residues Trp-318 and His-319 to their corresponding residues in kappa- and delta-opioid receptors provides the molecular basis for mu/delta selectivity and mu/kappa selectivity.	Histidine	87-90	opioid receptor kappa 1	Homo sapiens	130-163	
10945855-5	2000	Changes in EC(50) values for the W318L and W318Y/H319Y mu-opioid receptors show a partial contribution of these residues to the decreased GIRK1/GIRK2 channel activation by fentanyl analogs through kappa- and delta-opioid receptors.	Fentanyl	172-180	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	138-143	
10945855-5	2000	Changes in EC(50) values for the W318L and W318Y/H319Y mu-opioid receptors show a partial contribution of these residues to the decreased GIRK1/GIRK2 channel activation by fentanyl analogs through kappa- and delta-opioid receptors.	Fentanyl	172-180	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	144-149	
10945855-5	2000	Changes in EC(50) values for the W318L and W318Y/H319Y mu-opioid receptors show a partial contribution of these residues to the decreased GIRK1/GIRK2 channel activation by fentanyl analogs through kappa- and delta-opioid receptors.	Fentanyl	172-180	opioid receptor kappa 1	Homo sapiens	197-230	
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	4-fluorofentanyl	44-60	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	223-228	
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	4-fluorofentanyl	44-60	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	229-234	
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	4-fluorophenylpropanamide	105-130	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	223-228	
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	4-fluorophenylpropanamide	105-130	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	229-234	
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	Tryptophan	163-166	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	223-228	
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	Tryptophan	163-166	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	229-234	
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	Histidine	175-178	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	223-228	
10945855-6	2000	The most pronounced effect was observed for p-fluorofentanyl, suggesting that an interaction between the 4-fluorophenylpropanamide moiety of the drug and residues Trp-318 and His-319 is important for the resulting enhanced GIRK1/GIRK2 channel activation through the mu-opioid receptor.	Histidine	175-178	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	229-234