Title : TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.

Pub. Date : 2000 Aug 18

PMID : 10833508






3 Functional Relationships(s)
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1 BDNF was also found to directly stimulate channel phosphorylation because Kir3.1 immunoprecipitated from BDNF-stimulated cells showed enhanced labeling by anti-phosphotyrosine-specific antibodies. Phosphotyrosine potassium inwardly rectifying channel subfamily J member 3 Homo sapiens
2 The BDNF effect required specific tyrosine residues in the amino terminus of Kir3.1 and Kir3.4 channels. Tyrosine potassium inwardly rectifying channel subfamily J member 3 Homo sapiens
3 These results suggest that neurotrophin activation of TrkB receptors may physiologically control neuronal excitability by direct tyrosine phosphorylation of the Kir3.1 and Kir3.4 subunits of G protein-gated inwardly rectifying potassium channels. Tyrosine potassium inwardly rectifying channel subfamily J member 3 Homo sapiens