Pub. Date : 2000 Mar 10
PMID : 10719211
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we analyzed the effects of acute and chronic cocaine and morphine on mRNAs encoding the NGFI-B/Nur77 family of nuclear orphan receptors in reward pathways in Fischer and Lewis rats. | Cocaine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 2 | In this study, we analyzed the effects of acute and chronic cocaine and morphine on mRNAs encoding the NGFI-B/Nur77 family of nuclear orphan receptors in reward pathways in Fischer and Lewis rats. | Cocaine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 3 | In this study, we analyzed the effects of acute and chronic cocaine and morphine on mRNAs encoding the NGFI-B/Nur77 family of nuclear orphan receptors in reward pathways in Fischer and Lewis rats. | Morphine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 4 | In this study, we analyzed the effects of acute and chronic cocaine and morphine on mRNAs encoding the NGFI-B/Nur77 family of nuclear orphan receptors in reward pathways in Fischer and Lewis rats. | Morphine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 5 | After a single injection of cocaine, a similar upregulation of NGFI-B mRNA in striatal subregions and cortex cinguli was seen in both Fischer and Lewis rats. | Cocaine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 6 | Morphine increased NGFI-B mRNA in medial caudate putamen and cortex cinguli in Lewis rats and Nor1 mRNA in medial caudate putamen in Fischer rats. | Morphine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 7 | Chronic cocaine upregulated NGFI-B mRNA in nucleus accumbens core, lateral caudate putamen and cingulate cortex in Fischer rats, whereas no effect was seen in Lewis rats. | Cocaine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |
| 8 | Our results demonstrate different responses in addiction-prone Lewis rats as compared to the less addiction-prone Fischer rats with respect to NGFI-B and Nor1 mRNA regulation after acute and repeated administration of cocaine and morphine. | Cocaine | nuclear receptor subfamily 4, group A, member 1 | Rattus norvegicus |