Pub. Date : 1999 Nov-Dec
PMID : 10697568
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Taxotere activates transcription factor AP-1 in association with apoptotic cell death in gastric cancer cell lines. | Docetaxel | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | We investigated whether a novel mitotic inhibitor, taxotere can activate the transcription factor AP-1 in association with apoptotic cell death in 8 gastric cancer cell lines. | Docetaxel | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | The activation of AP-1 binding was induced in accordance with the sensitivity to taxotere in gastric cancer cell lines. | Docetaxel | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | The relationship between the increase of AP-1 binding and the formation of internucleosomal DNA ladders induced by taxotere was significant (p < 0.05). | Docetaxel | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 5 | Furthermore, the activation of AP-1 binding was induced following the treatment of taxotere in a dose and -time dependent manner. | Docetaxel | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 6 | These results indicate that the activation of AP-1 binding by taxotere seems to be an important factor in determining its sensitivity in association with internucleosomal DNA ladders, and suggest that the induction of gadd153 gene could be a downstream target of AP-1-regulated genes involved in signal transduction pathways leading to apoptosis in gastric cancer cells. | Docetaxel | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 7 | These results indicate that the activation of AP-1 binding by taxotere seems to be an important factor in determining its sensitivity in association with internucleosomal DNA ladders, and suggest that the induction of gadd153 gene could be a downstream target of AP-1-regulated genes involved in signal transduction pathways leading to apoptosis in gastric cancer cells. | Docetaxel | DNA damage inducible transcript 3 | Homo sapiens |
| 8 | These results indicate that the activation of AP-1 binding by taxotere seems to be an important factor in determining its sensitivity in association with internucleosomal DNA ladders, and suggest that the induction of gadd153 gene could be a downstream target of AP-1-regulated genes involved in signal transduction pathways leading to apoptosis in gastric cancer cells. | Docetaxel | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |