Pub. Date : 1999 Dec 3
PMID : 10607882
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It is well known that activation of the cloned kappa-opioid receptor by nanomolar concentrations of U50488H (trans-(+/-)-3, 4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl-benzeneacetamide) , a selective kappa-opioid receptor agonist, leads to the opening of GIRK1 channels. | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 2 | It is well known that activation of the cloned kappa-opioid receptor by nanomolar concentrations of U50488H (trans-(+/-)-3, 4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl-benzeneacetamide) , a selective kappa-opioid receptor agonist, leads to the opening of GIRK1 channels. | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 3 | We also show that micromolar concentrations of U50488H reduce GIRK1/GIRK2 current through direct GIRK1/GIRK2 channel block in a voltage-independent manner (IC(50)=70.28+/-3.68 microM). | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 4 | We also show that micromolar concentrations of U50488H reduce GIRK1/GIRK2 current through direct GIRK1/GIRK2 channel block in a voltage-independent manner (IC(50)=70.28+/-3.68 microM). | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 5 | Similarly, it was found that propoxyphene, methadone, and naloxone also can block GIRK1/GIRK2 current. | Dextropropoxyphene | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 6 | Similarly, it was found that propoxyphene, methadone, and naloxone also can block GIRK1/GIRK2 current. | Methadone | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 7 | Similarly, it was found that propoxyphene, methadone, and naloxone also can block GIRK1/GIRK2 current. | Naloxone | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |