Pub. Date : 1999 Sep 10
PMID : 10509562
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVES: To determine the effect of the protease inhibitors ritonavir, nelfinavir and indinavir on the P-glycoprotein (P-gp)-mediated transport of saquinavir in Caco-2 cell monolayers. | Nelfinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | OBJECTIVES: To determine the effect of the protease inhibitors ritonavir, nelfinavir and indinavir on the P-glycoprotein (P-gp)-mediated transport of saquinavir in Caco-2 cell monolayers. | Nelfinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | To study the modulation of P-gp function in human lymphocytes by saquinavir, ritonavir, nelfinavir and indinavir. | Nelfinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSIONS: We have demonstrated that saquinavir is a substrate for P-gp and that ritonavir, nelfinavir and indinavir modulate P-gp function in both human lymphocytes and Caco-2 cells. | Nelfinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |