Pub. Date : 1999 Oct
PMID : 10508828
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesized that glutathione depletion activates matrix metalloproteinases (MMPs), thereby increasing degradation of the alveolar extracellular matrix (ECM) during sepsis. | Glutathione | matrix metallopeptidase 2 | Rattus norvegicus |
| 2 | Ethanol ingestion increased (p < 0.05) MMP-9 and MMP-2 activity, as determined by zymography, in the lung tissue and lavage fluid compared with control-fed rats, and increased (p < 0.05) levels of the 7S fragment of type IV collagen in the lung lavage fluid. | Ethanol | matrix metallopeptidase 2 | Rattus norvegicus |
| 3 | Ethanol ingestion increased activation, but not production, of the MMP-9 and MMP-2 zymogens. | Ethanol | matrix metallopeptidase 2 | Rattus norvegicus |
| 4 | Finally, although concomitant ingestion of N-acetylcysteine had no effect (p > 0.05) on MMP production, it increased (p > 0.05) lung glutathione levels, blocked (p < 0.05) MMP-9 and MMP-2 activation, and decreased (p < 0.05) levels of the 7S fragment of type IV collagen. | Acetylcysteine | matrix metallopeptidase 2 | Rattus norvegicus |
| 5 | We conclude that chronic ethanol ingestion, via glutathione depletion, activates MMPs during sepsis, thereby increasing degradation of the alveolar epithelial ECM. | Ethanol | matrix metallopeptidase 2 | Rattus norvegicus |
| 6 | We conclude that chronic ethanol ingestion, via glutathione depletion, activates MMPs during sepsis, thereby increasing degradation of the alveolar epithelial ECM. | Glutathione | matrix metallopeptidase 2 | Rattus norvegicus |