PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10508828-3	1999	We hypothesized that glutathione depletion activates matrix metalloproteinases (MMPs), thereby increasing degradation of the alveolar extracellular matrix (ECM) during sepsis.	Glutathione	21-32	matrix metallopeptidase 2	Rattus norvegicus	80-84	
10508828-5	1999	Ethanol ingestion increased (p < 0.05) MMP-9 and MMP-2 activity, as determined by zymography, in the lung tissue and lavage fluid compared with control-fed rats, and increased (p < 0.05) levels of the 7S fragment of type IV collagen in the lung lavage fluid.	Ethanol	0-7	matrix metallopeptidase 9	Rattus norvegicus	42-47	
10508828-5	1999	Ethanol ingestion increased (p < 0.05) MMP-9 and MMP-2 activity, as determined by zymography, in the lung tissue and lavage fluid compared with control-fed rats, and increased (p < 0.05) levels of the 7S fragment of type IV collagen in the lung lavage fluid.	Ethanol	0-7	matrix metallopeptidase 2	Rattus norvegicus	52-57	
10508828-6	1999	Ethanol ingestion increased activation, but not production, of the MMP-9 and MMP-2 zymogens.	Ethanol	0-7	matrix metallopeptidase 9	Rattus norvegicus	67-72	
10508828-6	1999	Ethanol ingestion increased activation, but not production, of the MMP-9 and MMP-2 zymogens.	Ethanol	0-7	matrix metallopeptidase 2	Rattus norvegicus	77-82	
10508828-7	1999	Finally, although concomitant ingestion of N-acetylcysteine had no effect (p > 0.05) on MMP production, it increased (p > 0.05) lung glutathione levels, blocked (p < 0.05) MMP-9 and MMP-2 activation, and decreased (p < 0.05) levels of the 7S fragment of type IV collagen.	Acetylcysteine	43-59	matrix metallopeptidase 9	Rattus norvegicus	181-186	
10508828-7	1999	Finally, although concomitant ingestion of N-acetylcysteine had no effect (p > 0.05) on MMP production, it increased (p > 0.05) lung glutathione levels, blocked (p < 0.05) MMP-9 and MMP-2 activation, and decreased (p < 0.05) levels of the 7S fragment of type IV collagen.	Acetylcysteine	43-59	matrix metallopeptidase 2	Rattus norvegicus	191-196	
10508828-8	1999	We conclude that chronic ethanol ingestion, via glutathione depletion, activates MMPs during sepsis, thereby increasing degradation of the alveolar epithelial ECM.	Ethanol	25-32	matrix metallopeptidase 2	Rattus norvegicus	81-85	
10508828-8	1999	We conclude that chronic ethanol ingestion, via glutathione depletion, activates MMPs during sepsis, thereby increasing degradation of the alveolar epithelial ECM.	Glutathione	48-59	matrix metallopeptidase 2	Rattus norvegicus	81-85