Pub. Date : 1999 Apr 1
PMID : 10359460
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antibodies directed against CYP1A2 and CYP3A inhibited formation of CLZ N-oxide in human liver microsomes by 10.7+/-6.1%) and 37.2+/-6.9% of control, respectively, whereas CLZ N-demethylation was inhibited by 32.2+/-15.4% and 33.6+/-7.4%, respectively. | clozapine N-oxide | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | Antibodies directed against CYP1A2 and CYP3A inhibited formation of CLZ N-oxide in human liver microsomes by 10.7+/-6.1%) and 37.2+/-6.9% of control, respectively, whereas CLZ N-demethylation was inhibited by 32.2+/-15.4% and 33.6+/-7.4%, respectively. | clozapine N-oxide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Formation in stable expressed enzymes indicated involvement of CYP3A and CYP1A2 in CLZ N-oxide formation and CYP2D6, CYP1A2 and CYP3A4 in CLZ N-demethylation. | clozapine N-oxide | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Formation in stable expressed enzymes indicated involvement of CYP3A and CYP1A2 in CLZ N-oxide formation and CYP2D6, CYP1A2 and CYP3A4 in CLZ N-demethylation. | clozapine N-oxide | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |