Pub. Date : 1999 Mar 26
PMID : 10085101
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Within this region, GIRK2 has an aspartate at position 226, whereas GIRK1 has an asparagine at the equivalent position (217). | Asparagine | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 2 | PIP2 dramatically increased the open probability of GIRK1/GIRK2 channels in the absence of Na+ or Gbetagamma but did not preclude further activation by Na+, suggesting that Na+ is not acting simply to promote PIP2 binding to GIRKs. | Phosphatidylinositol 4,5-Diphosphate | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 3 | PIP2 dramatically increased the open probability of GIRK1/GIRK2 channels in the absence of Na+ or Gbetagamma but did not preclude further activation by Na+, suggesting that Na+ is not acting simply to promote PIP2 binding to GIRKs. | gbetagamma | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 4 | PIP2 dramatically increased the open probability of GIRK1/GIRK2 channels in the absence of Na+ or Gbetagamma but did not preclude further activation by Na+, suggesting that Na+ is not acting simply to promote PIP2 binding to GIRKs. | Phosphatidylinositol 4,5-Diphosphate | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 5 | We conclude that aspartate 226 in GIRK2 plays a crucial role in Na+-dependent gating of GIRK1/GIRK2 channels. | Aspartic Acid | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |