Pub. Date : 1999 Feb 1
PMID : 9973225
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This was evidenced by the fact that chemotherapy agents that synergized with TRAIL (e.g., doxorubicin) themselves caused cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP), and their toxicity was blocked by the caspase inhibitor Z-Val-Ala-Asp(OMe)-CH2 (ZVAD-fmk). | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 2 | Incubation of cell lines with doxorubicin or 5-fluorouracil significantly augmented TRAIL-induced apoptosis in most breast cell lines. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |
| 3 | Augmentation of TRAIL-induced apoptosis by doxorubicin or 5-fluorouracil was mediated through caspase activation. | Doxorubicin | TNF superfamily member 10 | Homo sapiens |