Pub. Date : 1999 Feb 5
PMID : 9920937
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lysophosphatidic acid activates NF-kappaB in fibroblasts. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | In the present study, we investigated the possibility that LPA activates the transcription factor NF-kappaB. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | We find that LPA causes a marked activation of NF-kappaB in Swiss 3T3 fibroblasts as determined by the degradation of IkappaB-alpha in the cytosol and the emergence of kappaB binding activity in nuclear extracts. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | The data demonstrate the utilization of multiple pathways in the activation of NF-kappaB by LPA, not inconsistent with the relevance of several families of GTP-binding regulatory proteins. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |