Title : Differential decreases in c-fos and aldolase C mRNA expression in the rat cerebellum after repeated administration of methamphetamine.

Pub. Date : 1999 Jan 22

PMID : 9889345






7 Functional Relationships(s)
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1 Differential decreases in c-fos and aldolase C mRNA expression in the rat cerebellum after repeated administration of methamphetamine. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 A single dose of methamphetamine induced c-fos mRNA expression in granule and Purkinje cells of both anterior and posterior lobes. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 Repeated methamphetamine injections reduced methamphetamine-induced c-fos mRNA signals in the anterior hemisphere and in part of the posterior vermis (lobule VII) and posterior hemisphere. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
4 Repeated methamphetamine injections reduced methamphetamine-induced c-fos mRNA signals in the anterior hemisphere and in part of the posterior vermis (lobule VII) and posterior hemisphere. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
5 Aldolase C mRNA signals in Purkinje cells decreased only in lobules where methamphetamine-induced c-fos signals were not reduced (lobules VI and IX). Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
6 Therefore, differential decreases in c-fos mRNA and aldolase C mRNA expression after repeated methamphetamine administration depend upon the localization of Purkinje cells in the cerebellum. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
7 Since c-fos mRNA and aldolase C mRNA expressions are markers of excitability and the metabolic state of Purkinje cells, respectively, hypofunction of inhibitory Purkinje cells could be induced if methamphetamine is repeatedly injected. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus